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Phenytoin 100 mg capsule; dizocilpine mg; phenobarbital 600 mg, as added codeine. Other antiemetics included lorazepam, meprobamate, and ketamine, combinations of propranolol phenobarbital. Treatment was commenced by a 15-minute intravenous infusion of 25 mg bolus dose sodium amytal. Participants were followed for a maximum of 30 days after discontinuation for further evaluations of changes in vital signs, psychiatric status, and adverse events. All study procedures were approved by the Institutional Review Boards of University Minnesota and Boston University. Study participants' written informed consent was obtained prior to all phases of the study. Treatment Protocol Adherence to study medication was assessed by urine sampling. Patients receiving the propranolol protocol were instructed to take their prescribed dose in the morning. Those receiving phenobarbital protocol were instructed to take their doses in the afternoon. Urine samples after administration of all four study medications, as well when discontinuing any study medication, were collected at the discretion of study author (R.G.L.) through self-collection devices (Vidiotec, Cambridge, MA) that were removed from the patient's clothing and taped to the interior surface of patient's buttocks. Samples were obtained between 3 and 15 minutes after administration of the study medication. Psychiatric Status Psychiatric status was assessed by standardized questionnaires. generic phenytoin vs dilantin Two of this study's principal investigators (R.G.L., A.L.S.) administered the Minnesota Multiphasic Personality Inventory (MMPI; Wechsler, Los Angeles, CA) as a means to assess psychiatric symptoms; 1 of the principal investigators (M.V., K.M.) administered the Beck Depression Inventory (BDI; Beck, Palo Alto, CA) as a means to assess depressive symptoms. Patients with a clinical diagnosis of manic or mixed psychoses psychotic symptoms major depression received additional psychiatric evaluation by a multidisciplinary team from the Minnesota State Clinical Research Center (Clinical Case Management Team, MNSCR; Department of Psychiatry, University Minnesota Medical School; Department of Psychiatry, Boston University School Medicine). This team included psychiatrists, psychologists, psychiatric nurses, clinical social workers, and family therapists. Assessment of Vital Signs All canada drug online vital signs were obtained by the investigators immediately after baseline urine specimens were collected and at 3 15 minutes after oral administration of the study medications. Urinalysis specimens were obtained for sodium fluoride, tritium, carbon dioxide, and urea using an automated centrifugal colorimetric assays on an AutoDex 3000 System, Siemens Allegros, Palo Alto, CA; and for potassium fluoride using a portable colorimetric kit (Nabisco Healthcare Corp, Stamford, CT). Plasma urea nitrogen was assayed on an automated centrifugal colorimetric system (Ebony Corp, Los Angeles, CA). Data Collection Efficacy evaluations were performed at 7, 14, 28, and 90 days from randomization. A second set of efficacy evaluations was conducted from 30 days to 45 after randomization.
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